Microstructure and Properties of Polyhydroxybutyrate-Chitosan-Nanohydroxyapatite Composite Scaffolds

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Microstructure and Properties of Polyhydroxybutyrate-Chitosan-Nanohydroxyapatite Composite Scaffolds

Polyhydroxybutyrate-chitosan-hydroxyapatite (PHB-CHT-HAP) composite scaffolds were prepared by the precipitation of biopolymer-nanohydroxyapatite suspensions and following lyophilisation. The propylene carbonate and acetic acid were used as the polyhydroxybutyrate and chitosan solvents, respectively. The high porous microstructure was observed in composites and the macroporosity of scaffolds (p...

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Response of human mesenchymal stem cells to intrafibrillar nanohydroxyapatite content and extrafibrillar nanohydroxyapatite in biomimetic chitosan/silk fibroin/nanohydroxyapatite nanofibrous membrane scaffolds

Incorporation of nanohydroxyapatite (nHAP) within a chitosan (CS)/silk fibroin (SF) nanofibrous membrane scaffold (NMS) may provide a favorable microenvironment that more closely mimics the natural bone tissue physiology and facilitates enhanced osteogensis of the implanted cell population. In this study, we prepared pristine CS/SF NMS, composite CS/SF/nHAP NMS containing intrafibrillar nHAP by...

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Properties of calcium carbonate-containing composite scaffolds.

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Nanohydroxyapatite-reinforced chitosan composite hydrogel for bone tissue repair in vitro and in vivo

BACKGROUND Bone loss during trauma, surgeries, and tumor resection often results in critical-sized bone defects that need to be filled with substitutionary materials. Complications associated with conventional grafting techniques have led to the development of bioactive tissue-engineered bone scaffolds. The potential application of hydrogels as three-dimensional (3D) matrices in tissue engineer...

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chitosan and nanohydroxyapatite roles in physical and chemical characteristics of gelatin/chitosan/nanohydroxyapatite microspheres

the effects of chitosan/biopolymer (c/p) and nanohydroxyapatite/ biopolymer (nha/p) weight ratios on particle size and its uniformity, cross-linking density and nh2 content of nano-hydroxyapatite/chitosan/gelatin (nha/c/g) microspheres were investigated. microspheres were fabricated using water-in-oil emulsion. cross-linking of microspheres was performed using water soluble carbodiimide. partic...

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ژورنال

عنوان ژورنال: The Scientific World Journal

سال: 2012

ISSN: 1537-744X

DOI: 10.1100/2012/537973